Omar Khalid Khorasani led Jamaat-ul-Ahrar, a Pakistani Taliban faction behind several high-profile bombings in Pakistan.
Nine other militants were killed next to him in the drone attack, the group spokesman said.
Local media reported more and more drone attacks last week.
Nearly 40 people have been killed on the border, many of which are supposed to be militant.
Khorasani’s death comes before a visit by US Foreign Secretary Rex Tillerson in Pakistan.
According to analysts, Islamabad urged Washington to attack militants attacking within Pakistan and hiding across the border in Afghanistan.
Jamaat-ul-Ahrar admitted that last year, on Ostersonntag, he had committed bomb attacks on Christians in a park in Lahore, killing at least 70 people, including 29 children
It also said that it was behind the suicide attack on a hospital in Quetta that killed at least 74 people.
In recent days there have been rumors that Khorasani was injured during US drone attacks on the border and his group confirmed his death on Thursday.
“The head of our Jamaat-ul-Ahrar, Omar Khalid Khorasani, who suffered serious injuries in a US drones attack in the Afghan province of Paktia, was injured on Wednesday night,” spokesman Asad Mansoor told the AFP news agency by telephone.
“At least nine close Khorasani employees were also killed in the strike,” he added.
He confirmed the news when he spoke to the Reuters news agency.
In 2014, Jamaat-ul-Ahrar pledged to the Islamic state, but a year later, it said that it had resumed the Pakistani Taliban, which is allied with al-Qaeda.
Khorasani was seriously injured in a NATO air strike in eastern Afghanistan in 2015 but recovered from his injuries.